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KMID : 0371319940460050724
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Journal of the Korean Surgical Society
1994 Volume.46 No. 5 p.724 ~ p.731
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The Relationship between Helicobacter pylori Infection and Infantile Hypertrophic Pyloric Stenosis in Infants
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문상웅
심육택/이남혁/김상윤
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Abstract
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The potential role of Helicobacter pylori(H. pylori, formerly called Campylobacter pylori) in fection as causes of infantile hypertrophic pyloric stenosis (IHPS) and postoperative vomiting was evaluated with an enzyme-linked immunosorbent
assay(ELISA)
for detecting H. pylori-specific IgG in the patients group and control group. Serum samples were collected were collected prospectively from 38 infants with IHPS and 38 infants without upper gastrointestinal symptoms as a control group.
H. pyloir-specific IgG antibody was present in 55.3% of the patients and 23.7% of the control group(p<0.004). Mean IgG antibody titers(optical density titers) in both groups were 222.1±138.9 and 130.2±34.3, respectively which showed also
statistically significant difference. In the patients group, there wre no statistically significant differences between IgG antibody positive and negative patients in duraiton and severity of clinical symptoms, degree of metabolic alkalosis(PH),
and
size of the hypertrophied pyloric muscle mass. And the incidence of postoperative vomiting did not correlate with H. pylori infection. Postoperative change of IgG antibody titers examined by serial ELISAs showed gradual decrease following
pyloromyotomy
and changed into negative on examinations performed a month after operation except 2 who had high titers initially.
I. On the basis of this prospoctive study, we concluded that H. pylori infection did not correlate with the etiologies of IHPS and postoperative vomiting but stasis of gastric content may offer suitable environment for H. pylori infection and
subsequent development of gastritis which may play some role for early postoperative vomiting. ELISA for H. pylori-specific IgG antibody may be a useful guide in diagnosis of H.pylori infection and evaluation of therapeutic response against H.
pylori
infection. In addition, we found that H. pylori infection occurs early in life even in neonatal period and H. pylori infection may be occurred through the transoral route via mother's or artificial nipple
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KEYWORD
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